1. Aminoglucose-functionalized, redox-responsive polymer ...
Nov 28, 2017 · This study focused on aminoglucose-functionalized, redox-responsive copolymer AG-P-SS-P vesicles as a novel hydrophilic anticancer drug delivery ...
Chemotherapeutic drugs used for cancer therapy frequently encounter multiple-drug resistance (MDR). Nanoscale carriers that can target tumors to accumulate and release drugs intracellularly have the greatest potential for overcoming MDR. Glucose transporter-1 (GLUT-1) and glutathione (GSH) overexpression in cancer cells was exploited to assemble aminoglucose (AG)-conjugated, redox-responsive nanomicelles from a single disulfide bond-bridged block polymer of polyethylene glycol and polylactic acid (AG-PEG-SS-PLA). However, whether this dual functional vector can overcome MDR in lung cancer is unknown. In this experiment, AG-PEG-SS-PLA was synthetized successfully, and paclitaxel (PTX)-loaded AG-PEG-SS-PLA (AG-PEG-SS-PLA/PTX) nanomicelles exhibited excellent physical properties. These nanomicelles show enhanced tumor targeting as well as drug accumulation and retention in MDR cancer cells. Caveolin-dependent endocytosis is mainly responsible for nanomicelle internalization. After internalization, the disulfide bond of AG-PEG-SS-PLA is cleaved in the presence of high intracellular glutathione levels, causing the hydrophobic core to become a polar aqueous solution, which subsequently results in nanomicelle disassembly and the rapid release of encapsulated PTX. Reduced drug resistance was observed in cancer cells in vitro. The caspase-9 and caspase-3 cascade was activated by the AG-PEG-SS-PLA/PTX nanomicelles through upregulation of the pro-apoptotic proteins Bax and Bid and suppr...
2. 6-Amino-6-deoxy-D-glucose Hydrochloride | CAS 55324-97-5
6-Amino-6-deoxy-D-glucose Hydrochloride is an amino sugar studied for irreversible enzyme inhibition. CAS Number: 55324-97-5. Molecular Weight: 215.63.
Buy 6-Amino-6-deoxy-D-glucose Hydrochloride (CAS 55324-97-5), an amino sugar studied for irreversible enzyme inhibition, from Santa Cruz. MF: C6H14ClNO5
3. Amino Sugars | DrugBank Online
Drug, Drug Description. Glucosamine, A common ingredient in nutritional supplements used for the relief of joint pain.
4. Aminoglycosides Use in Animals - Merck Veterinary Manual
Aminoglycosides are mostly bactericidal drugs that share chemical, antimicrobial, pharmacological, and toxic characteristics.
Learn about the veterinary topic of Aminoglycosides Use in Animals. Find specific details on this topic and related topics from the Merck Vet Manual.
5. Amino Sugars | Synthose
Buy Amino Sugars from Synthose.
6. Chiral vanadium(v) complexes with 2-aminoglucose Schiff-base ligands ...
Chiral vanadium(v) complexes with 2-aminoglucose Schiff-base ligands and their solution configurations: synthesis, structures, and DFT calculations†.
See Also25100 N 104Th WayThe sugar-modified Schiff-base ligands derived from benzyl 2-deoxy-2-salicylideneamino-α-d-glucopyranoside (H2L5-Br and H2L3-OMe) were used to prepare the chiral oxidovanadium(v) complexes [VO(L5-Br)(OMe)] (1) and [VO(L3-OMe)(OMe)] (2) which can be isolated from a methanol solution as the six-coordinate comp
7. KEGG PATHWAY: Amino sugar and nucleotide sugar metabolism
Pathway modules. Carbohydrate metabolism. Other carbohydrate metabolism. M00549 Nucleotide sugar biosynthesis; M00554 Nucleotide sugar biosynthesis
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8. Two New Amino-Sugars from an Antigenic Polysaccharide ... - Nature
Two amino-sugars, designated 'pneumosamine' and 'amino-sugar X' have been isolated from purified Type V Pneumococcus capsular polysaccharide3, and preliminary ...
THOUGH a large number of antigenic capsular polysaccharides of Pneumococcus are known to contain one or more amino-sugars1, in only one case, namely, 2-amino-2-deoxy-D-glucose (D-glucosamine) from type XIV polysaccharide2, has the amino-sugar been isolated and characterized. Two amino-sugars, designated ‘pneumosamine’ and ‘amino-sugar X’ have been isolated from purified Type V Pneumococcus capsular polysaccharide3, and preliminary investigations, which included analysis of the crystalline N-acetamido alcohol derivatives, indicated that both sugars were 2-amino-2,6-dideoxyhexoses. Kuhn-Roth determinations on ‘N-acetylpneumosaminol’ (1.52 moles CH3) and on ‘amino-sugar X’ (0.68 mole CH3) support the postulated 6-deoxyhexosamine structure. The sugars have now been tentatively identified as 2-amino-2,6-dideoxytalose (pneumosamine) and 2-amino-2,6-dideoxy-L-galactose (amino-sugar X). The sugars were isolated from a polysaccharide hydrolysate (hydrolysis conditions: 2 N hydrochloric acid, 24 hr., 100°) by chromatography on ‘Dowex-50’ resin4. The acidic effluents were neutralized with ‘Deacidite FF’ (carbonate form), lyophilized and the syrupy residues dried in vacuo over phosphorus pentoxide. Treatment of the ‘pneumosamine’ residue with methanol gave ‘pneumosamine hydrochloride’ melting point 162–3° (from methanol–ether); [α]18 D + 6.9° (10 min.), → + 10.4° equil. (cone. 2.3 in water). Found: C, 35.9; H, 7.4 per cent; calc. for C6H14O4NCl: C, 36.1; H, 7.1 per cent. ‘Amino-sugar X’...
9. Amino Sugars Analysis Service - Creative Proteomics
What are Amino Sugars? Amino sugars are chemical compounds that have a sugar backbone, in which one of the hydroxyl groups is replaced by an amine group.
Creative Proteomics specializes in amino sugar analysis using advanced HPLC and MS technologies, catering to diverse research and industrial needs.
10. Amino sugar | chemistry - Britannica
Sep 10, 2024 · Amino sugars (i.e., sugars in which one or two hydroxyl groups are replaced with an amino group, ―NH2) occur as components of glycolipids and in ...
Other articles where amino sugar is discussed: monosaccharide: Amino sugars (i.e., sugars in which one or two hydroxyl groups are replaced with an amino group, ―NH2) occur as components of glycolipids and in the chitin of arthropods.
